Single-pass laser-arc hybrid welding of Q235/304 stainless clad steel plate (SCSP) was studied by employing three types of commercial austenite stainless filling wires with different Cr content to develop alternatives to low efficient multi-pass welding methods. In this research, the morphology, element distribution, microstructure, and mechanical properties of the welding joints were investigated. Results show that the SCSP have a good laser-arc hybrid weldability, and the cross-section morphology of welding joints present a typical nail shape without pores and cracks. The Cr content of the welding wire affects the viscosity of the weld pool, then significantly change the heat and mass transfer process. With the increase of Cr content of the welding wire, the dilution ratio of the carbon steel layer to stainless steel layer increase gradually, and the depth of the alloy element enrichment zone in the welding joints (LZ) decrease from 4.78 mm to 2.7 mm, while the content of Cr in the arc zone (AZ) only slightly increased. And the content of martensite in the AZ reduces gradually, leading to its microhardness decreases from 390 HV to 215 HV. Moreover, the LZ of all welding joints is mainly composed of martensite, leading to its microhardness and the tensile strength of welding joints higher than that of the base metal.