Since before the first studies of Endre Mester with the Ruby laser where he showed accelerated wound healing, biophotonics has demonstrated transformational solutions in Medicine. This talk will present a review of several successes biophotonics has had in Medicine and new opportunities. Devices including Laser Scribing, OCT, Refractive Lasers, and Femtosecond Laser-Assisted Cataract Surgery have transformed the standard of care in Medicine. As we look back and to the future, what is next for biophotonics in Medicine? Transformation of aphakic IOLs? COVID-19 detection? Drug fabrication? Regenerative Medicine? The potential of biophotonics continues to solve many challenging problems in Medicine. This talk will address these and other relevant topics to biophotonics.